| 新金鸡纳生物碱衍生物配体的合成及其在烯烃的不对称双羟化反应中的应用 |
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| 引用本文： | 何炜,张生勇,姜茹,孙晓莉,张磊,沈颂章.新金鸡纳生物碱衍生物配体的合成及其在烯烃的不对称双羟化反应中的应用[J].分子催化,2005,19(6):440-443. |
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| 作者姓名： | 何炜 张生勇 姜茹 孙晓莉 张磊 沈颂章 |
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| 作者单位： | 第四军医大学,药学系,化学教研室,陕西,西安,710032 |
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| 摘 要： | 以简便的方法高产率地合成四种金鸡纳生物碱的对甲苯磺酸酯类配体，并将其应用于烯烃的不对称双羟化反应中，取得了较好的不对称诱导效果，双羟化反应的化学产率为82％～95％，对映体过量最高达93％ee．
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| 关 键 词： | 金鸡纳生物碱 不对称双羟化 手性连二醇 |
| 文章编号： | 1001-3555(2005)06-0440-04 |
| 收稿时间： | 2005-02-21 |
| 修稿时间： | 2005-05-08 |
Synthesis of Cinchonatosylates Ligands and Their Application in Asymmetric Dihydroxylation of Olefins |
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| HE Wei,ZHANG Sheng-yong,JIANG Ru,SUN Xiao-li,ZHANG Lei,SHEN Song-zhang.Synthesis of Cinchonatosylates Ligands and Their Application in Asymmetric Dihydroxylation of Olefins[J].Journal of Molecular Catalysis (China),2005,19(6):440-443. |
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| Authors: | HE Wei ZHANG Sheng-yong JIANG Ru SUN Xiao-li ZHANG Lei SHEN Song-zhang |
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| Abstract: | Four cinchonatosylates ligands were prepared by easy procedure in high chemical yields.The investigation of their asymmetric induction in asymmetric dihydroxylation of olefinshas been carried out.Chemical yields of chiral vicinal diols were 82%~95%,and moderate to excellent enantioselectivity(up to 93% ee) were obtained. |
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| Keywords: | Cinehonatosylates ligands Asymmetric dihydroxylation Chiral vieinal diols |
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