Glycopeptide antibiotics and development of inhibitors to overcome vancomycin resistance |
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Authors: | Gao Yong |
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Affiliation: | Department of Chemistry and Biochemistry, Southern Illinois University at Carbondale, 62901-4409, USA. ygao@chem.siu.edu |
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Abstract: | This review outlines the history of vancomycin and other key glycopeptide antibiotics and the molecular basis of vancomycin resistance, and focuses on the development of synthetic inhibitors of vancomycin-resistant enzymes VanR, S, A, H and X to overcome resistance. The literature up to July 2001 is reviewed and 119 references are cited. |
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