| 双核铜(Ⅱ)-氟喹诺酮-邻菲咯啉混配配合物的合成、晶体结构和抗肿瘤活性 |
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| 引用本文： | 王国平,傅旭春,朱龙观.双核铜(Ⅱ)-氟喹诺酮-邻菲咯啉混配配合物的合成、晶体结构和抗肿瘤活性[J].无机化学学报,2003,19(9):1001-1005. |
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| 作者姓名： | 王国平 傅旭春 朱龙观 |
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| 作者单位： | 1. 浙江大学化学系,杭州,310027
2. 浙江大学城市学院药学系,杭州,310015 |
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| 基金项目： | 国家自然科学基金资助项目(No.50073019)。 |
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| 摘 要： | A new binuclear copper (Ⅱ) complex with 1,10-phen and fluoroquinolone ligands, Cu2(cfc)2(phen)2(pip)](NO3)2(CO)2,was synthesized and its crystal structure was solved.The formula of the complex is C28H24ClCuFN5O7, and the crystallography data are as follows, triclinic, space group P1, a=0.80372(6)nm, b=0.94712 (7)nm, c=1.67826(13)nm, α=88.5650(10)°, β=80.9920(10)°, γ=70.2780(10)°, V=1.18722(6)nm3, Z=2, D=1.848g· cm-3, F(000)=676. R1=0.0627 and wR2=0.1684 (I>2σ(I)). The copper atom is five- coordinate with square-based pyramidal geometry and involves two nitrogen atoms from phen, two oxygen atoms from cfc and one nitrogen atom from pip anion. The stacking effect between cfc and phen ligands from two neighboring molecules was observed. FT-IR spectrum of the complex was also discussed. Both ligand and complex were assayed against gram-positive and gram-negative bacteria by doubling dilutions method； the complex shows the same mini-mal inhibitory concentration (MIC) as the corresponding ligand against S. Aureus, E. Coli and M. Lutens bac-teria. The inhibitory effect of the ligand and complex on leukemia HL-60 cell line and liver cancer BEL-7402 cell line have been measured by using MTT (Methyl-Thiazol- Tetrozolium) and SRB (Sulphurhodamin B) assay meth-ods, respectively. The results indicated that the complex has strong inhibitory effect on HL-60 and BEL-7402 cell line. CCDC: 203964.
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| 关 键 词： | 双核铜(Ⅱ)配合物 氟喹诺酮 环丙沙星 合成 晶体结构 抗菌与抗肿瘤活性 |
| 修稿时间： | 2003年3月12日 |
Synthesis, Crystal Structure, Antibacterial and Antitumor Activities of a New Binuclear Copper (Ⅱ) Complex with 1, 10-phen and Fluoroquinolone |
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| WANG Guo-Ping,FU Xu-Chun and ZHU Long-Guan.Synthesis, Crystal Structure, Antibacterial and Antitumor Activities of a New Binuclear Copper (Ⅱ) Complex with 1, 10-phen and Fluoroquinolone[J].Chinese Journal of Inorganic Chemistry,2003,19(9):1001-1005. |
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| Authors: | WANG Guo-Ping FU Xu-Chun and ZHU Long-Guan |
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| Institution: | Department of Chemistry, Zhejiang University, Hangzhou 310027,Department of Pharmacy, City College, Zhejiang University, Hangzhou 310015 and Department of Chemistry, Zhejiang University, Hangzhou 310027 |
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| Abstract: | |
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| Keywords: | copper complex fluoroquinolone ciprofloxacin synthesis crystal structure antibacterial and antitumor activity |
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