Asymmetric synthesis of (+)-isofebrifugine and (-)-sedacryptine from a common chiral nonracemic building block |
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Authors: | Wee Andrew G H Fan Gao-Jun |
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Affiliation: | Department of Chemistry and Biochemistry, University of Regina, Regina, Saskatchewan, Canada S4S 0A2. andrew.wee@uregina.ca |
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Abstract: | The stereoselective syntheses of 2-substituted and 2,6-disubstituted 3-hydroxypiperidine alkaloids, (+)-isofebrifugine and (-)-sedacryptine, from a common, functionalized nonracemic bicyclic building block are achieved, demonstrating the flexibilty of the approach. |
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