N-[3-nitro(amino)coumarin-4-yl]anthranilic acid amides. Synthesis of 6,7,8,13-tetrahydro[1]benzopyrano[4,3-b][1,4] benzodiazepine-6,8-dione |
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Authors: | V L Savel'ev O S Artamonova A V Makarov V S Troitskaya A V Antonova V G Vinokurov |
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Institution: | (1) Scientific-Research Institute of Pharmacology, Academy of Medical Sciences of the USSR, 125315 Moscow |
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Abstract: | The reaction of 3-nitro-4-chlorocoumarin with anthranilic acid was used to synthesize N-(3-nitro-4-coumarinyl)-anthranilic acid, from which, through the acid chloride, we obtained a number of amides, which were reduced to N-(3-amino-4-coumarinyl)anthranilic acid amides The latter are cyclized under the influence of hydrochloric acid to 6,7,8,13-tetrahydro1]benzopyrano-4,3-b]1, 4]benzodiazepine-6,8-dione, which was also obtained from N-(3-amino-4-coumarinyl)anthranilic acid by its thermolysis or treatment with hydrochloric acid.See 1] for our preliminary communication.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 9, pp. 1208–1212, September, 1989. |
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