Kinetics and mechanism of the reaction between aquacobalamin and isoniazid |
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Authors: | S O Tumakov I A Dereven’kov D S Salnikov S V Makarov |
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Institution: | 1.Ivanovo State University of Chemistry and Technology,Ivanovo,Russia |
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Abstract: | Kinetics of the reaction of aquacobalamin (H2OCbl) with isoniazid (isonicotinic acid hydrazide, INH) in weakly alkaline, neutral, and weakly acidic media was studied using UV–Vis spectroscopy. It is shown that the reversible formation of a complex more stable than those of cobalamin(III) with pyridine and hydrazine occurs during the reaction. A mechanism of the reaction includes reversible stages of binding a neutral INH molecule by cobalamin(III) through an oxygen atom with its subsequent deprotonation, along with the reversible interaction of H2OCbl and the negatively charged form of INH. |
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