Stereoselective synthesis and hormonal activity of novel dafachronic acids and naturally occurring steroids isolated from corals |
| |
| Authors: | Saini Ratni Boland Sebastian Kataeva Olga Schmidt Arndt W Kurzchalia Teymuras V Knölker Hans-Joachim |
| |
| Affiliation: | Department Chemie, Technische Universit?t Dresden, Bergstrasse 66, 01069 Dresden, Germany. |
| |
| Abstract: | A stereoselective synthesis of (25S)-Δ(1)-, (25S)-Δ(1,4)-, (25S)-Δ(1,7)-, (25S)-Δ(8(14))-, (25S)-Δ(4,6,8(14))-dafachronic acid, methyl (25S)-Δ(1,4)-dafachronate and (25S)-5α-hydroxy-3,6-dioxocholest-7-en-26-oic acid is described. (25S)-Δ(1,4)-Dafachronic acid and its methyl ester are natural products isolated from corals and have been obtained by synthesis for the first time. (25S)-5α-Hydroxy-3,6-dioxocholest-7-en-26-oic acid represents a promising synthetic precursor for cytotoxic marine steroids. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
