Asymmetric synthesis and absolute configuration of streptophenazine G |
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Authors: | Yang Zhicai Jin Xiaomin Guaciaro Michael Molino Bruce F |
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Institution: | Medicinal Chemistry Department, AMRI, 26 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098, USA. zhicai.yang@amriglobal.com |
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Abstract: | The asymmetric synthesis of the antibacterial natural product, streptophenazine G, has been achieved by employing asymmetric alkylation and asymmetric aldol reactions using chiral oxazolidinones as the key steps. The originally proposed structure for streptophenazine G has been revised, and its absolute configuration has been determined to be 1'S,2'R,6'S. The asymmetric total synthesis of 6'-epi-streptophenazine G is also described. |
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