A novel magnetic triple-responsive composite semi-IPN hydrogels for targeted and controlled drug delivery |
| |
| Authors: | Yinjuan Huang Mingzhu Liu Jiucun Chen Chunmei Gao Qiuyu Gong |
| |
| Affiliation: | 1. Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China;2. Key Laboratory of Solid Lubrication, Chinese Academy of Sciences, Lanzhou Institute of Chemical Physics, Lanzhou 730000, PR China |
| |
| Abstract: | In this work, Fe3O4/poly(3-acrylamidephenylboronic acid-co-(2-dimethylamino) ethyl methacrylate) (Fe3O4/P(AAPBA-co-DMAEMA)) hydrogels possessing magnetic and triple-responsive properties and semi-interpenetrated by β-cyclodextrin-epichlorohydrin (β-CD-EPI) were prepared via radical polymerization. The characteristics of the materials have been investigated by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM). The swelling measurements and the application of Fe3O4/P(AAPBA-co-DMAEMA)/(β-CD-EPI) hydrogels in controlled release of drug were also investigated. It was found that the magnetic hydrogels exhibit swelling behaviors affected by pH, temperature, glucose concentration and magnetic field, and have porous morphologies, superparamagnetism. Moreover, the hydrogels possess targeting and could control the release of quercetin by adjusting pH value, temperature, glucose concentration and magnetic field. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
