Radiation synthesis of acrylic acid/polyethyleneimine interpenetrating polymer networks (IPNs) hydrogels and its application as a carrier of atorvastatin drug for controlling cholesterol |
| |
| Authors: | Horia MM Nizam El-Din Abdel Wahab M El-Naggar |
| |
| Institution: | 1. Polymer Chemistry Department, National Center for Radiation Research and Technology, P.O. Box 29, Nasr City, Cairo, Egypt;2. Radiation Chemistry Department, National Center for Radiation Research and Technology, P.O. Box 29, Nasr City, Cairo, Egypt |
| |
| Abstract: | Gamma irradiation was used to form interpenetrating polymer networks structure (IPNs) hydrogels based on different ratios of acrylic acid monomer (AAc) and polyethyleneimine (PEI). The property-behavior was characterized by IR spectroscopy, gel content, thermogravimetric analysis (TGA) and swelling in water at room temperature and different pH values. The AAc/PEI hydrogels were used as a carrier for atorvastatin drug, in which the uptake-release character was studied. The results showed that the gel content of AAc/PEI hydrogels decreased greatly with increasing the ratio of PEI in the initial feeding solution. The AAc/PEI hydrogels displayed pH-sensitive character. The drug uptake-release study indicated that AAc/PEI hydrogels possessed controlled release behavior and that the release process depends on pH. In this respect, the release of atorvastatin drug was significant in acidic medium. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
