Isolation,NMR spectroscopy,and conformational analysis of the antibiotic ina 2770 (cineromycin B) produced by Streptomyces strain |
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| Authors: | L. P. Terekhova O. A. Galatenko V. V. Kulyaeva N. D. Malkina Yu. V. Boikova G. S. Katrukha A. S. Shashkov A. G. Gerbst N. E. Nifantiev |
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| Affiliation: | (1) G. F. Gause Institute of New Antibiotics, Russian Academy of Medical Sciences, 11 ul. Bol’shaya Pirogovskaya, 119021 Moscow, Russian Federation;(2) N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation |
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| Abstract: | The antibiotic INA 2770 active against methicillin-resistant staphylococcus aureus (MRSA) was biotechnologically produced and isolated. This antibiotic is identical to cineromycin B. The characteristic features of the 1H and 13C NMR spectra of this compound were studied for the first time, and the conformational analysis was carried out by computational methods (molecular mechanics (MM3) force field) and using nuclear Overhauser effect experiments. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 784–787, April, 2007. |
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| Keywords: | lactones cineromycin B antibiotics macrocyclic compounds actinomycetales 1H NMR spectra |
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