Physicochemical characterization of tamoxifen citrate pseudopolymorphs, methanolate and ethanolate |
| |
Authors: | Kojima Takashi Kato Fumie Teraoka Reiko Matsuda Yoshihisa Kitagawa Shuji Tsuhako Mitsutomo |
| |
Affiliation: | Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Higashi-Nada, Kobe, Japan. tak_kojimajpn@yahoo.co.jp |
| |
Abstract: | Two novel pseudopolymorphs, methanolate and ethanolate of tamoxifen [(Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine]citrate, were prepared in addition to forms A and B reported previously. Their crystalline forms were identified and characterized by powder and single crystal X-ray diffractometry, differential scanning calorimetry, thermogravimetric analysis, hot-stage microscopy, scanning electron microscopy and diffuse reflectance infrared Fourier-transform spectroscopy, and their physicochemical stability was also evaluated. The results of single crystal X-ray analysis and thermogravimetric analysis of methanolate and ethanolate suggested that the stoichiometry of tamoxifen citrate : methanol and tamoxifen citrate : ethanol could be composed of a 1 : 1 molecular ratio for both solvates. The results of physicochemical stability evaluations at 75 and 97% RH at 40 and 60 degrees C indicated that the metastable form A was quite stable for at least 2 months even under severe storage conditions, whereas methanolate immediately transformed to a crystalline mixture of forms A and B, and subsequently changed to the stable form B. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|