4-Hydroxy-2-quinolones. 152*. 3-acetyl-4-hydroxy-2-oxo-1,2-dihydroquinoline and its biologically active derivatives |
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Authors: | I V Ukrainets A A Tkach Liu Yang Yang |
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Institution: | (1) National University of Pharmacy, Kharkiv, 61002, Ukraine |
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Abstract: | A synthesis and study of the spatial structure of 3-acetyl-4-hydroxy-2-oxo-1,2-dihydroquinoline have been carried. 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic
acids 1-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)ethylidene]hydrazides were prepared from this compound by two routes. A
comparative analysis of the antitubercular properties of the synthesized compounds and of the closely structurally related
N,N′-di(1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)hydrazines has been performed.
*For Communication 151 see 1].
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 214–222, February, 2009. |
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Keywords: | 3-acetyl-4-hydroxy-2-oxo-1 2-dihydroquinolines acetoacetic ester hydrazides hydrazones 1-R-4-hydroxy-2-oxo-1 2-dihydroquinoline-3-carboxylic acids antitubercular activity X-ray structural analysis |
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