| 高效液相色谱手性固定相法直接拆分外消旋雷诺嗪 |
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| 引用本文： | 张红丽,柳春辉,赵艳芳,明永飞,李永民,陈立仁.高效液相色谱手性固定相法直接拆分外消旋雷诺嗪[J].分析试验室,2006,25(4):97-100. |
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| 作者姓名： | 张红丽 柳春辉 赵艳芳 明永飞 李永民 陈立仁 |
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| 作者单位： | 中国科学院兰州化学物理研究所,兰州,730000 |
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| 基金项目： | 国家重点基础研究发展计划(973计划);中国科学院"百人计划" |
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| 摘 要： | 在反相以及正相争件下，利用自制的涂敷型纤维素-三（3，5-二甲基苯基氨基甲酸酯）手性固定相直接拆分了外消旋雷诺嗪，并考察了不同流动相对手性拆分的影响，特别是醇类物质对拆分影响。结果表明，醇的立体结构、极性对雷诺嗪的手性拆分均有影响。实验结果显示无论在正相条件下还是在反相条件下，涂敷型纤维素-三（3，5-二甲基苯基氨基甲酸酯）手性固定相均可以很好的拆分外消旋体雷诺嗪。
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| 关 键 词： | 高效液相色谱 手性拆分 雷诺嗪 手性固定相 纤维素-三(3 5-二甲基苯基氨基甲酸酯) |
| 文章编号： | 1000-0720（2006）04-097-04 |
| 收稿时间： | 06 3 2005 12:00AM |
| 修稿时间： | 2005-06-032005-09-10 |
Direct chiral separation of racemic ranolazine by high performance liquid chromatography with chiral stationary phase |
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| ZHANG Hong-li,LIU Chun-hui,ZHAO Yan-fang,MING Yong-fei,LI Yong-ming,CHEN Li-ren.Direct chiral separation of racemic ranolazine by high performance liquid chromatography with chiral stationary phase[J].Chinese Journal of Analysis Laboratory,2006,25(4):97-100. |
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| Authors: | ZHANG Hong-li LIU Chun-hui ZHAO Yan-fang MING Yong-fei LI Yong-ming CHEN Li-ren |
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| Institution: | Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000 |
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| Abstract: | In normal and reverse phase conditions,the direct chiral separation of the ranolazine was performed on cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase,which was made in our lab.The influence of alcohol in mobile phase on chiral separation was investigated.The results showed that the steric structure and polar of alcohol affected chiral separation of the ranolazine.The experimental results showed that the ranolazine was separated easily in normal and reverse phase conditions. |
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| Keywords: | High performance liquid chromatogrophy Ranolazine Chiral separation cellulose tris(3 5-dimethylphenylcarbamate)(CDMPC) Chiral stationary phase |
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