Replacement of dimethylpyrazolyl group in 1,2,4,5-tetrazines by aliphatic alcohols and water |
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| Authors: | R I Ishmetova N I Latosh I N Ganebnykh N K Ignatenko S G Tolshchina G L Rusinov |
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| Institution: | (1) Postovskii Institute of Organic Synthesis, Ural Division, Russian Academy of Sciences, ul. S. Kovalevskoi/Akademicheskaya 22/20, Yekaterinburg, 620041, Russia |
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| Abstract: | Reactions of 3,6-bis(4-R-3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazines and 3-amino-6-(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazines with aliphatic alcohols and water in the presence of a base involved replacement of the dimethylpyrazolyl group and resulted in the formation of mono- and dialkoxy-1,2,4,5-tetrazines and 6-substituted 3-hydroxy-1,2,4,5-tetrazines. Dissociation constants of the latter were determined by potentiometric titration. |
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