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Strategy-Level Separations in Organic Synthesis: From Planning to Practice
Authors:Dennis P. Curran
Abstract:A dirty word in synthesis: separation! The normally unavoidable separation at the end of each reaction finds no friends among synthetic chemists and is often regarded as a technical procedure. However, the need to quickly and cheaply produce pure products is driving the development of new separation and purification techniques. Astonishingly, the modern concepts and techniques for coupling synthesis and separation are rooted in workup procedures that are as old as the art of synthesis itself.
Keywords:Combinatorial chemistry  Fluorous synthesis  Solid-phase synthesis  Synthesis design
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