Highly Efficient,Catalytic Meerwein–Ponndorf–Verley Reduction with a Novel Bidentate Aluminum Catalyst |
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Authors: | Takashi Ooi Tomoya Miura Keiji Maruoka |
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Abstract: | Double electrophilic activation of carbonyl groups allows a modern variant of the Meerwein–Ponndorf–Verley reduction to be carried out under mild conditions with bidentate catalyst 1 (see reaction). Various carbonyl substrates can be reduced efficiently at room temperature in CH2Cl2 with 2-propanol or sec-phenethyl alcohol in the presence of a catalytic amount of 1 . This system is also applicable to the Oppenauer oxidation of secondary alcohols to the corresponding ketones. |
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Keywords: | Aluminum Asymmetric synthesis Homogeneous catalysis Oxidations Reductions |
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