Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis |
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Authors: | Helen E. Blackwell Robert H. Grubbs |
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Abstract: | Olefin metathesis has been successfully applied to the synthesis of macrocyclic helical peptides [Eq. (a)]. Carbon–carbon bond tethers between amino acid side chains were introduced by ring-closing metathesis. This macrocyclization protocol is a novel and mild procedure for introducing nonnative covalent cross-links into peptide helices. |
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Keywords: | Carbene complexes Helical structures Macrocycles Metathesis Peptides |
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