Extended Calixpyrroles: meso-Substituted Calix[6]pyrroles

A 1,3,5- alternate conformation of the pyrrole rings is adopted by the calix6]pyrrole 1 in the crystal (see picture). Compound 1 was synthesized in a two-step process and although it crystallizes in the form of the adduct 1 ⋅3CH₃COCH₃⋅H₂O⋅CHCl₃, there are no solvent molecules in the cavity (cross section ca. 60Ų) of this macrocycle which possesses alternating dimethyl and diphenyl substitutents at the meso positions.