Synthesis of Optically Active α-Amino- phosphinic Acids by Catalytic Asymmetric Hydrogenation in Organic Solvents and Aqueous Micellar Media |
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Authors: | Torsten Dwars,Ute Schmidt,Christine Fischer,Ingrid Grassert,Rhett Kempe,Roland Frö hlich,Karlheinz Drauz,Gü nther Oehme |
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Abstract: | Enantiomeric excesses of up to 99 % could be obtained in the synthesis of the biologically interesting acylated α-aminophosphinic acids 1 (R1=Me, Ph; R2=H, Me, Et; R3=H, F, iPr) by asymmetric hydrogenation with rhodium complex catalysts and subsequent hydrolysis [Eq. (1)]. cod=1,5-cyclooctadiene. |
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Keywords: | Aminophosphinic acids Asymmetric catalysis Hydrogenations Rhodium |
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