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trans-[RuCl2(phosphane)2(1,2-diamine)] and Chiral trans-[RuCl2(diphosphane)(1,2-diamine)]: Shelf-Stable Precatalysts for the Rapid,Productive, and Stereoselective Hydrogenation of Ketones |
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| Authors: | Henri Doucet Takeshi Ohkuma Kunihiko Murata Tohru Yokozawa Masami Kozawa Eiji Katayama Anthony F. England Takao Ikariya Ryoji Noyori |
| Abstract: | A turnover number (TON) of 2 400 000 and a turnover frequency (TOF) of 63 s−1 are achieved with the chiral RuII complex 1 (R=p-CH3C6H4) in the asymmetric hydrogenation of acetophenone. Carbonyl-selective asymmetric hydrogenation of α,β-unsaturated ketones proceeds in the presence of these RuII catalysts, and 4-substituted cyclohexanones are selectively converted into cis alcohols. |
| Keywords: | Asymmetric catalysis Chiral alcohols N ligands P ligands Ruthenium |