Direct Observation of Radical Intermediates While Investigating the Redox Behavior of Thiamin Coenzyme Models |
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Authors: | Ikuo Nakanishi Shinobu Itoh Tomoyoshi Suenobu Shunichi Fukuzumi |
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Abstract: | The redox behavior of “active aldehydes” 1 − derived from 3-benzylthiazolium salts and simple aldehydes in the presence of a base has been examined with low-temperature cyclic voltammetry and EPR spectroscopy. The highly negative oxidation potentials of 1 − and the spin distribution of the intermediate radicals 1 . indicate that the active aldehyde can act as an efficient electron mediator in thiamin-dependent enzymatic redox systems. |
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Keywords: | Coenzymes Cyclic voltammetry EPR spectroscopy Radicals Thiamin |
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