Abstract: | Just like in biological systems , the GAPDH-catalyzed oxidation of aldehyde to carboxylate proceeds in conjunction with 1,4-selective reduction of NAD+ to NADH model compounds Eq. (1)]. The combination of GAPDH- and LDH-type transfer reactions is also described here as a system mimic for the NAD+/NADH redox cycle in anaerobic glycolysis. GAPDH=D -glyceraldehyde-3-phosphate dehydrogenase, LDH=L -lactate dehydrogenase. |