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The Total Synthesis of Eleutherobin: A Surprise Ending |
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| Authors: | Xiao-Tao Chen Bishan Zhou Samit K. Bhattacharya Clare E. Gutteridge Thomas R. R. Pettus Samuel J. Danishefsky |
| Abstract: | An “sp 2 –sp 3 Stille coupling” of the vinyl triflate 1 and the stannyl compound 2 is a key step toward the completion of the total synthesis of eleutherobin, a natural product exhibiting taxol-like cytotoxic activity. |
| Keywords: | Antitumor agents Eleutherobin Glycosylations Stille coupling Total synthesis |