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Chemical Synthesis of a Circular Protein Domain: Evidence for Folding-Assisted Cyclization |
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| Authors: | Julio A Camarero Joanna Pavel Tom W Muir |
| Abstract: | Extremely fast cyclization of the linear polypeptide precursor 1 takes place to form 2 . The reaction appears to be assisted by the native fold of 1 , which positions the reactive ends in close proximity. The circular topology has no influence on the folding or function of 2 . |
| Keywords: | Cyclizations Peptides Protein structures Solid-phase synthesis |