| Abstract: | A peptide fragment with the 140–146 sequence of the main component of the surrace protein of the hepatitis B virus (HBsAG) and a number of its structural analogues have been synthesized by the classical method in solution. Conjugates of the peptides synthesized with bovine serum albumin and with a synthetic polypeptide analogue of polytuftsin have been obtained. The ability of the preparations to bind antibodies from the blood sera of hepatitis B patients has been studied. The possibility has been shown of their use for revealing antibodies to the heptatitis B virus in solid-phase enzyme-mediated immunoassay.Leningrad State University. Translated from Khimiya Prirodnykh Soedinenii, Nos. 3,4, pp. 406–413, May–August, 1992. |
