Synthesis of a fluorous ligand and its application for asymmetric addition of dimethylzinc to aldehydes |
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| Authors: | Sokeirik Yasser S Mori Hiroyuki Omote Masaaki Sato Kazuyuki Tarui Atsushi Kumadaki Itsumaro Ando Akira |
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| Institution: | Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Japan. |
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| Abstract: | A new fluorous ligand was synthesized from the acetonide of dimethyl tartarate, which showed excellent asymmetric induction on the addition of dimethylzinc to aldehydes. This ligand will be useful for synthesis of bioactive compounds with a methyl carbinol moiety. It could be recycled without using a fluorous solvent or a fluorous column. |
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