Charting calcium-regulated apoptosis pathways using chemical biology: role of calmodulin kinase II |
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| Authors: | Maria Hägg Olofsson Aleksandra Mandic Havelka Slavica Brnjic Maria C Shoshan Stig Linder |
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| Affiliation: | (1) From the Cancer Center Karolinska, Department of Oncology-Pathology, Karolinska Institute, S-171 76 Stockholm, Sweden |
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| Abstract: | Background Intracellular free calcium ([Ca2+]i) is a key element in apoptotic signaling and a number of calcium-dependent apoptosis pathways have been described. We here used a chemical biology strategy to elucidate the relative importance of such different pathways. |
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