Detrimental effects of tropisetron on permanent ischemic stroke in the rat |
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| Authors: | Eduardo Candelario-Jalil Eduardo Muñoz Bernd L Fiebich |
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| Institution: | 1.Neurochemistry Research Group, Department of Psychiatry,University of Freiburg Medical School,Freiburg,Germany;2.Department of Neurology,University of New Mexico Health Sciences Center,Albuquerque,USA;3.Departamento de Biología Celular,Fisiología e Inmunología. Universidad de Córdoba,Córdoba,Spain;4.VivaCell Biotechnology GmbH,Denzlingen,Germany |
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| Abstract: | Background Recent in vitro evidence indicates that blockade of 5-hydroxytryptamine (5-HT) receptor 3 (5-HT3) is able to confer protection in different models of neuronal injury. The purpose of the present study was to investigate
the effect of tropisetron, a 5-HT3 receptor antagonist, on infarct size and neurological score in a model of ischemic stroke induced by permanent middle cerebral
artery occlusion (pMCAO) in the rat. |
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