Synthese von rac-threo und rac-erythro-α-(2, 2-Dichloracetamido)-β-hydroxy-p-nitrohydrozimtaldehyd

rac-threo-α-(2, 2-Dichloroacetamido)-β-hydroxy-p-nitrohydrocinnamaldehyde (3) and rac-erythro-α-(2, 2-dichloroacetamido)-β-hydroxy-p-nitrohydrocinnamaldehyde (4) were synthesized starting from α-acetamido-p-nitroacetophenone (7) , and their structures were proved b^n? reduction to rac-chloramphenicol (19) and rac-erythro-2-(2, 2-dichloroacetamido)-1-(p-nitrophenyl)^v 1, 3-propanediol (14) respectively. 3 exhibited only low antibacterial activity compared to rac-chloramphenicol (19) .