Nucleoside analogs. I. A synthesis of 1,3-dihydroxy-2-(6-substituted-9-purinyl)cyclohexane

Biologically active 1,3-dihydroxy-2-(6-substituted-9-purinyl)cyclohexanes (VI-X) were prepared by a reaction between trans-2-amino-1,3-cyclohexanediol (I) and 4,6-dichloro-5-amino-pyrimidine (II), followed by cyclization and nucleophilic substitution. Compounds VI and VII showed a weak inhibitory effect against Xanthomonas oryzae, a pathogenic bacteria of leaf blight of rice plant.