A convergent strategy for the synthesis of polycyclic ethers by using oxiranyl anions |
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Authors: | Sakai Takeo Sugimoto Ai Mori Yuji |
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Institution: | Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Nagoya 468-8503, Japan. |
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Abstract: | A new X+2+Y]-type for the convergent synthesis of polycyclic ethers based on an oxiranyl anion strategy was developed. The sequence involves nucleophilic substitution of a triflate with an oxiranyl anion followed by 6-endo cyclization, ring expansion, and reductive etherification. The protocol features a flexible approach toward trans-fused polycyclic arrays consisting of six- and seven-membered ether rings from the same starting materials. |
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