Copper(I) catalyzed regioselective asymmetric alkoxyamination of aryl enamide derivatives |
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| Authors: | Nakanishi Masafumi Minard Corinne Retailleau Pascal Cariou Kevin Dodd Robert H |
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| Institution: | Institut de Chimie des Substances Naturelles, UPR 2301 CNRS, Avenue de la Terrasse, 91198 Gif-Sur-Yvette, France. |
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| Abstract: | The copper(I) catalyzed reaction of an enamide with an iminoiodane, in the presence of an alcohol, triggers the direct alkoxyamination of the double bond. This transformation represents a straightforward access to α-amino aminals in a completely regio- and diastereoselective manner. Use of a chiral Box ligand allows this reaction to be carried out in an enantioselective fashion. |
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