Concise formal synthesis of (+)-neopeltolide |
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| Authors: | Yang Zhen Zhang Bingbin Zhao Gaoyuan Yang Juan Xie Xingang She Xuegong |
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| Affiliation: | State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China. |
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| Abstract: | A concise formal synthesis of (+)-neopeltolide (1) has been accomplished. The synthesis demonstrated high atom efficiency employing only one step of functional group protection. Key steps involved iridium-catalyzed double asymmetric carbonyl allylation, palladium-catalyzed intramolecular alkoxycarbonylation, ruthenium-catalyzed olefin isomerization, and ring-closing metathesis. |
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