Determination of platinum in urine by differential pulse polarography |
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| Authors: | Vrána O Kleinwächter V Brabec V |
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| Institution: | Institute of Biophysics, Czechoslovak Academy of Sciences, 612 65 Brno, Czechoslovakia. |
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| Abstract: | A method has been developed for determination of platinum in urine, after administration of cis-dichlorodiammineplatinum(II). The diethyldithiocarbamate complex of the platinum(II) is formed and extracted into chloroform, then mineralized with aqua regia. After removal of nitric acid the platinum is complexed with ethylenediamine. This chelate yields a catalytic current at a dropping mercury electrode, which is measurable by differential pulse polarography. The detection limit is ~10 ng ml . The calibration graph is linear over the range 20-800 ng ml . |
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| Keywords: | To whom correspondence and reprint requests should be directed |
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