Simultaneous determination of acetaminophen and dextropropoxyphene napsylate in pharmaceutical preparations by reverse phase HPLC |
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Authors: | Sa'sa' S Rashid A Jalal I |
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Institution: | Yarmouk University, Irbid, Jordan. |
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Abstract: | The method reported provides a fast, sensitive, accurate and reproducible reverse-phase HPLC assay for acetaminophen and dextropropoxyphene simultaneously. The total elution time is < 5 min. The method is stability-indicating since it can also determine p-aminophenol, a degradation product of acetaminophen, in a concentration as low as 0.005% of the acetaminophen concentration. |
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