Heterocyclic derivatives of purines. 3. Synthesis and mass spectrometric study of imidazo[1,2-]purine

A mixture containing 65% 1-methyl-2-phenyl-5,7-dichloro- and 35% 1-methyl-2-phenyl-3,5,7-trichloroimidazo 1,2-f] purine (the percentages of the components were established by means of Chromatographic mass-spectrometric analysis) was obtained by refluxing 1,8-dimethyl-2-phenylimidazo 1,2-f]xanthine in POCl₃ in the presence of excess PCl₅. Reduction of this mixture with concentrated HCl in the presence of red phosphorus leads to 1-methyl-2-phenylimidazo1,2-f] purine, while heating with piperidine gives a mixture consisting of 55% 1-methyl-2-phenyl-6-piperidino-8-chloroimidazo 1,2-f] purine and 45% 1-methyl-2-phenyl-3, 8-dichloro-6-piperidino-imidazo 1,2-f] purine. The IR, PMR, and mass spectra of the compounds obtained are discussed.See 1] for communication 2.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1125–1129, August, 1980.