Obviously Enhanced Fluorescent Signal of Core-Shell Nanostructures through Simultaneous Regulation of Spectral Overlap and Shell Thickness for Imaging and Photothermal Therapy of Ovarian Cancer Cells |
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| Authors: | Xianyang Li Jingyuan Huang Xin Wu Xianling Piao Danning Lv Gude Zhang Dong June Ahn Chunzhi Cui |
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| Institution: | 1. Department of Chemistry, Yanbian University, Yanji, 133002 China;2. Department of Chemical and Biological Engineering, Korea University, Seoul, 0 3. 2841 South Korea;4. Affiliated Hospital of Yanbian University, Yanji, 133000 China;5. Interdisciplinary Program of Biological Functional Molecules, College of Integration Science, Yanbian University, Yanji, Jilin Province, 133002 China |
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| Abstract: | In this research, by simultaneously regulating the two major factors affecting the plasmonic enhanced fluorescence (PEF), spectral overlap and the distance between the fluororophores and the noble metal nanoparticles, a significantly enhanced fluorescent signal is achieved. Core-shell nanostructures composed of aspect ratio (AR) adjustable gold nanorods (GNRs) and various thickness of SiO2 are prepared and the decorated fluorophores are realized optimized PEF. A typical stimuli-responsive conjugated polymer, polydiacetylene (PDA), and a near-infrared (NIR) dye Cy5.5 are selected as fluorophores and their fluorescent signal are enhanced 7.26 and 4.41 times, respectively. Based on the optimized optical properties, a multifunctional antibody modified Mab-Cy5.5-GNRs@SiO2 is successfully demonstrated the targeting, imaging, and photothermal therapy (PTT) effects on SKOV-3 ovarian cancer cells. |
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| Keywords: | gold nanorods plasmon-enhanced fluorescence photothermal therapy |
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