Exploring the role of ligand-BSA in the response of BSA-protected gold-nanoclusters to silver (I) Ions by FT-IR and circular dichroism spectra |
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| Institution: | 1. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, No. 2699 Qianjin Street, Changchun 130012, China;2. College of Pharmacy, Jilin University, No.1266 Fujin road, Changchun 130021, China;1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China;2. University of Chinese Academy of Sciences, Beijing, 100039, China;1. Department of Chemistry, Shiraz University, Shiraz, Iran;2. Faculty of Science, Hormozgan University, Bandar Abbas, Iran;1. Department of Chemistry, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, PR China;2. Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, PR China;3. Translational Medicine Center, Shanxi Medical University, Taiyuan 030006, PR China;1. College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, 333 Longteng Road, Shanghai, 201620, PR China;2. School of Chemistry & Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China;3. College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Road, Shanghai, 201620, PR China;4. Xinjiang Deland CO., LTD. 216, Lantian Road, North Industrial Park, High-tech District, Urumqi, PR China |
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| Abstract: | Previously, we have explored the mechanism of the response of BSA-protected small gold nanoclusters (Au16NCs@BSA) to silver (I) ions (Ag+) by using XPS, but the role of the ligand BSA in this response was not clear. Therefore, we used FT-IR and circular dichroism (CD) spectra to monitor the changes of the secondary structure of ligand BSA. After adding Ag+ to the AuNCs@BSA, compare with the native BSA, the ligand-BSA showed little differences in the position of main peaks but more differences in the profile of this peak in FT-IR spectra. While in CD spectra it is not only peak shape changed but also peak position. All the results showed silver ions can bind to ligand BSA, and induced their secondary structure changes. But the changes of ligand BSA are not enough to influence the fluorescence emission of AuNCs@BSA, especially for the emission of AuNCs. And BSA-protected different size gold nanoclusters have the similar changes in spatial structure of ligand BSA, but only the Au16NCs@BSA could response to Ag+, which indicated that the ligand BSA was not the key role for the special fluorescent response. |
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| Keywords: | Gold nanoclusters Response Secondary structure Mechanism |
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