Recent progress in solid-state NMR studies of drugs confined within drug delivery systems |
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Affiliation: | 1. Facultad de Matemática, Astronomía y Física and IFEG (CONICET), Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba, X5000HUA, Argentina;2. Biophysics and Department of Chemistry, The University of Michigan, Ann Arbor, Michigan, 48109–1055;3. Department of Chemistry and the Macromolecular Science and Engineering Program, The University of Michigan, Ann Arbor, Michigan, 48109–1055;4. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA) CONICET-UNC and Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba, X5000HUA, Argentina |
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Abstract: | Recent progress in the application of solid-state NMR (SS NMR) spectroscopy in structural studies of active pharmaceutical ingredients (APIs) embedded in different drug carriers is detailed. This article is divided into sections. The first part reports short characterization of the nanoparticles and microparticles that can be used as drug delivery systems (DDSs). The second part shows the applicability of SS NMR to study non-steroidal anti-inflammatory drugs (NSAIDs). In this section, problems related to API–DDS interactions, morphology, local molecular dynamics, nature of inter- or intramolecular connections, and pore filling are reviewed for different drug carriers (e.g. mesoporous silica nanoparticles (MSNs), cyclodextrins, polymeric matrices and others). The third and fourth sections detail the recent applications of SS NMR for searching for antibiotics and anticancer drugs confined in zeolites, MSNs, amorphous calcium phosphate and other carriers. |
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Keywords: | Solid-state NMR Drug delivery systems Non-steroidal anti-inflammatory drugs Antibiotics Anticancer drugs |
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