| 多巴胺盐酸盐与二甲亚砜的相互作用研究 |
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| 引用本文： | 李丽纳,孙芳,马慧婷,郭晓锦,翟翠萍. 多巴胺盐酸盐与二甲亚砜的相互作用研究[J]. 化学通报, 2015, 78(10): 911-911 |
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| 作者姓名： | 李丽纳 孙芳 马慧婷 郭晓锦 翟翠萍 |
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| 作者单位： | 河南大学精细化学与工程研究所 开封 475004,河南大学精细化学与工程研究所 开封 475004,河南大学精细化学与工程研究所 开封 475004,河南大学精细化学与工程研究所,河南大学精细化学与工程研究所 开封 475004 |
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| 基金项目： | 河南省科技发展计划项目(144300510034, 142300410125)、河南省教育厅基金项目(15A150042)和河南大学大学生创新创业训练计划项目(15NA003) |
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| 摘 要： | 使用核磁共振技术、密度泛函理论(DFT)和分子中原子(AIM)理论,研究了多巴胺盐酸盐(DH)与二甲亚砜(DMSO)的相互作用。结果表明,DH中酚羟基和氨基正离子上的氢原子、苯环上位于酚羟基和侧链之间碳上的氢原子,甚至侧链上与苯环直接相连的亚甲基上的氢原子都可与DMSO中的氧原子形成分子间氢键。
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| 关 键 词： | 多巴胺盐酸盐 二甲亚砜 相互作用 核磁共振 量子化学计算 |
| 收稿时间： | 2015-04-18 |
| 修稿时间： | 2015-07-02 |
Study on the Interactions of Dopamine Hydrochloride with Dimethylsulfoxide |
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| Li Lin,Sun Fang,Ma Huiting,guo xiaojin and ZHAI Cuiping. Study on the Interactions of Dopamine Hydrochloride with Dimethylsulfoxide[J]. Chemistry, 2015, 78(10): 911-911 |
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| Authors: | Li Lin Sun Fang Ma Huiting guo xiaojin ZHAI Cuiping |
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| Affiliation: | Institute of Fine Chemical and Engineering,Henan University,Institute of Fine Chemical and Engineering,Henan University,Institute of Fine Chemical and Engineering,Henan University,Institute of Fine Chemical and Engineering, Henan University,Institute of Fine Chemical and Engineering,Henan University |
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| Abstract: | Interactions of dopamine hydrochloride (DH) with dimethylsulfoxide (DMSO) were investigated by NMR, DFT and atoms in molecules (AIM) theory. The results indicated that hydrogen bonds were formed by the oxygen atoms of DMSO molecules with the hydrogen atoms of phenolic hydroxyls, NH3 groups, and hydrogen atoms located on carbon atom between phenolic hydroxy and amino side chain of the benzene ring, and the hydrogen atoms of the methylene next to the benzene ring of DH. |
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| Keywords: | Dopamine Hydrochloride DMSO Interaction NMR Quantum Chemistry Calculation |
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