Boronate-mediated biologic delivery |
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Authors: | Ellis Gregory A Palte Michael J Raines Ronald T |
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Institution: | Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA. |
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Abstract: | Inefficient cellular delivery limits the landscape of macromolecular drugs. Boronic acids readily form boronate esters with the 1,2- and 1,3-diols of saccharides, such as those that coat the surface of mammalian cells. Here pendant boronic acids are shown to enhance the cytosolic delivery of a protein toxin. Thus, boronates are a noncationic carrier that can deliver a polar macromolecule into mammalian cells. |
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