| 驱镉剂N-(d-葡萄糖基)-L-氨基酸类化合物的1H NMR谱研究 |
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| 引用本文： | 王超,毛希安.驱镉剂N-(d-葡萄糖基)-L-氨基酸类化合物的1H NMR谱研究[J].波谱学杂志,1996,13(5):443-446. |
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| 作者姓名： | 王超 毛希安 |
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| 作者单位： | 1. 北京医科大学生源药物化学中德联合实验室, 北京 100083;2. 中国科学院武汉物理研究所波谱与原子分子物理国家重点实验室, 武汉 430071 |
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| 基金项目： | 卫生部基金和中科院武汉物理研究所波谱与原子分子物理国家重点实验室资助项目 |
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| 摘 要： | d-葡萄糖与L-氨基酸缩合制得一类新型驱隔剂,本文报道5种N-(d-葡萄糖基)-L-氨基酸的1H NMR.当氨基酸侧链上有含羟基、巯基及苄基一类的富电荷基时,葡萄糖基上的质子都移向高场,这可能与这些基团的存在不利于N-取代氨基酸生成内盐有关.动物实验表明:与甘氨酸的衍生物比较,它们的驱镉性能也较优秀,本文推测,不利于生成内盐的基因也可能有助于发挥驱镉效应.
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| 关 键 词： | d-葡萄糖 L-氨基酸 驱镉剂 1H NMR |
| 收稿时间： | 1996-03-13 |
1H NMR STUDY ON N-GLUCAMYL-AMINO ACIDS AS CADMIUM CHELATING AGENTS |
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| Wang Chao,Peng Shiqi,Mao Xian.1H NMR STUDY ON N-GLUCAMYL-AMINO ACIDS AS CADMIUM CHELATING AGENTS[J].Chinese Journal of Magnetic Resonance,1996,13(5):443-446. |
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| Authors: | Wang Chao Peng Shiqi Mao Xian |
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| Institution: | 1. Beijing Medical University, Beijing 100083;2. State Key Laboratory of Magnetic Resonance and Atomic and Moleculer Physics, Wuhan Institute of Physics, The Chinese Academy of Scineces, Wuhan 430071 |
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| Abstract: | A series of novel cadmium chelating agent, N-glueamyl-amino acids were synthesized. In the present paper their 1H NMR data are reported. The results indicate that when amino acid contain hydroxyl, thiol or benzy1 group as the side chain,the protons of glucamyl will shift up field. Perhaps these groups are disadvantageous for the formation of the internal salts of amino acids and will be responsible for the up field shift mentioned. The bioassy shows that these compounds containing special side chain are better than glycine derivative on cadmium excretion. |
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| Keywords: | D-Glucose L-Amino acid Cadmium chelating agent 1H NMR |
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