| 碳糊电极阳极吸附伏安法测定卡托普利 |
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| 引用本文： | 易伟,易兰花,费俊杰,黎拒难. 碳糊电极阳极吸附伏安法测定卡托普利[J]. 分析科学学报, 2012, 28(2): 230-232 |
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| 作者姓名： | 易伟 易兰花 费俊杰 黎拒难 |
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| 作者单位： | 1. 湘潭大学化学学院,环境友好化学与应用省部共建教育部重点实验室,湖南湘潭411105;湘潭大学兴湘学院,湖南湘潭411105
2. 山西大学化学化工学院,山西太原,030006 |
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| 基金项目： | 湖南省科技计划，湘潭大学自然科学基金，湖南省大学生创新性实验计划资助项目 |
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| 摘 要： | 在0.40 mol/L的HAc-NaAc(pH=4.8)缓冲溶液中,卡托普利(Captopril,CPT)在碳糊电极(CPE)上有一灵敏的吸附氧化峰,峰电位为0.23 V(vs.SCE)。该氧化峰的二阶导数峰电流与卡托普利的浓度在2.0×10-8～1.0×10-6mol/L(富集90 s)范围内呈良好的线性关系,相关系数为0.9966,检出限为8.0×10-9mol/L,并成功应用于卡托普利片含量的测定。探讨了卡托普利在碳糊电极上的伏安性质和电极反应机理。
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| 关 键 词： | 卡托普利 阳极吸附伏安法 碳糊电极 |
Anodic Adsorptive Voltammetric Determination of Captopril at a Carbon Paste Electrode |
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| YI Wei , YI Lan-hua , FEI Jun-jie , LI Ju-nan. Anodic Adsorptive Voltammetric Determination of Captopril at a Carbon Paste Electrode[J]. Journal of Analytical Science, 2012, 28(2): 230-232 |
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| Authors: | YI Wei YI Lan-hua FEI Jun-jie LI Ju-nan |
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| Affiliation: | 1(1.Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education,School of Chemistry,Xiangtan University,Xiangtan 411105; 2.Xingxiang College of Xiangtan University,Xiangtan 411105) |
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| Abstract: | A highly selective and rapid anodic adsorptive voltammetric method has been developed for the determination of trace amount of captopril at a carbon paste electrode(CPE)in the current paper.Captopril is adsorbed on the surface of the CPE in 0.40 mol/L HAc-NaAc buffer solution(pH=4.8),yielding one oxidation peak at 0.23 V(vs.SCE).The relationship between the peak current and captopril concentration is linear in the range of 2.0×10-8~1.0×10-6 mol/L with the correlation coefficient of 0.9966.The detection limit is 8.0×10-9 mol/L(S/N=3) for 90 s acummulation.The proposed method was applied to the direct determination of captopril in the captopril tablet with satisfactory results and the electrode reaction mechanism of captopril was investigated. |
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| Keywords: | Captopril Anodic adsorption voltammetry Carbon paste electrode |
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