THE HALOID DISPLACEMENT BY AMMONIA AND AMINES IN 2(3)-CHLORO-3(2)-ALKYLTHIO-2-METHYLPROPANOIC ACID DERIVATIVES |
| |
| Authors: | D Greiĉiute J Kulys L Rasteikiene |
| |
| Institution: | Institute of Biochemistry of the Academy of Sciences of the Lithuanian SSR , Vilnius, USSR |
| |
| Abstract: | Abstract The reaction of derivatives of 2(3)-chloro-3(2)-alkylthio-2-methylpropanoic acids with ammonia in nitromethane has been found to yield a mixture of 2-and 3-aminosubstituted compounds. With dimethylamine and diethylamine in nitromethane (sulfolane) a mixture of alkylamino-substituted products as well as HCl elimination products has been obtained. Pure diethylamine has been shown to form mainly the products of HCl elimination. A mechanism for the displacement and elimination reactions via formation of various episulphonium ions as intermediates has been suggested. |
| |
| Keywords: | |
|
