生物矿化研究中的化学模型

本文介绍了近年来生物矿化领域的研究情况,特别是从早期的有机-无机界面分子识别模型发展到介观组装和无定形前驱相转化模型的建立。与传统基于水溶液晶体生长的理解不同,人们发现在生物矿化过程中,在溶液中首先沉积的是胶体状的无定型前驱相,有机基质通过对无机相转化动力学及组装过程的控制实现矿物纳米晶体的有序组装,这为材料的仿生制备及生物医学应用提供了全新的策略。

Chemical Models for Biomineralization Studies

This article reviews the recent research achievements in biomineralization, especially the development from the original organic-inorganic interface molecular recognition model to recent mesoscopic assembly and precursor phase-based transformation models. Different from the classical atom/molecule mediated crystallization mechanisms, scientists have found that the colloidal amorphous phase deposits firstly in solution during biomineralization, then organic matrix induces and controls the organized assembly of the mineral nanoparticles via the pathways of phase transformation and assembly kinetics. This new understanding provides a new strategy for biomimetic synthesis and biomedical applications.