Compound Hub: efficiency gains through innovative sample management processes |
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Authors: | Schopfer Ulrich Andreae Marc R M Hueber Matthieu Saur Andreas Kummer Marcel O Girod Michel Fox Desmond Steiner Thomas Popov Maxim Smith Robert |
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Institution: | Novartis Institutes for BioMedical Research, Discovery Technologies, Basel, Switzerland. ulrich.schopfer@novartis.com |
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Abstract: | While significant investments are made across the industry and increasingly also in academia to enhance or build a compound file, the efficient sourcing of compounds from in-house medical chemistry is frequently seen as a challenge. This article introduces the Compound Hub strategy developed at the Novartis Compound Archive. Central Compound Hubs in Basel and Cambridge were combined with web-based ordering of compounds and assays, providing assay-ready, solubilized samples to labs anywhere in the global research organization. Relieving scientists from time-intensive sample preparation tasks, error rates could be reduced through electronic processing and tracking of compounds/assays and the capture of medicinal chemistry compounds for the compound library could be increased by 75%. |
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