Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents |
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| Authors: | Ying Menga Guan Wangb Yue Lia Kuan Houa Yue Yuana Li-Juan Zhanga Hong-Rui Songa Wei Shib a |
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| Institution: | Key Laboratory of Structure-Based Drug Design and Discovery,Ministry of Education,Shenyang Pharmaceutical University,Shenyang 110016,China b Key Laboratory for Molecular Enzymology and Engineering,Ministry of Education,Jilin University,Changchun 130012,China |
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| Abstract: | A series of pyrrolo1,2-a]pyrazinone compounds (5a–9f) were synthesized, and their cytotoxic activity against SKOV-3, A549, HeLa cells in vitro were evaluated by the MTT method. Some of the compounds showed potential antitumor activity against three tumor cell lines. Among them, compounds 9c and 9d showed the most potent cytotoxic activity. The preliminary mechanism of action was discussed. |
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| Keywords: | Pyrrolopyrazinone Antitumor Synthesis |
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