Libraries from libraries: Generation and comparison of screening profiles

Summary A positional scanning tetrapeptide library was chemically modified through alkylation and/or reduction of the amide bonds, thus generating three new combinatorial libraries with physico-chemical properties very different from the parent peptide library (libraries from libraries). Specific results were obtained with each of these libraries upon screening in -opioid receptor binding and microdilution antimicrobial assays, illustrating the potential of the libraries from libraries concept for the efficient generation of a variety of chemically diverse combinatorial libraries.