| Improved Synthesis of Icaritin and Total Synthesis of β-Anhydroicaritin |
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| 作者姓名： | TONG Jie LIU Chang WANG Bo |
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| 作者单位： | CAS Key Laboratory of High-petformance Synthetic Rubber and Its Composite Materials;University of Chinese Academy of Sciences;University of Science and Technology of China |
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| 基金项目： | the National Natural Science Foundation of China |
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| 摘 要： | Natural products icaritin and β-anhydroicaritin with P-glycoprotein(P-gp) inhibitory activities were ciently synthesized in nine steps from commercially available phloroglucinol. A modified Algar-Flynn-Oyamada cyclization and relay Claisen-Cope rearrangement were employed in this concise route. Oiir synthesis offers opportunities to synthesize various icariin analogues for biological and pharmacological investigations.
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| 关 键 词： | ICARITIN FLAVONOL Regioselectivity Algar-Flynn-Oyamada |
| 收稿时间： | 2019-01-14 |
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